overview
Castleman’s disease is a rare disease in which cells in your body’s lymph nodes overgrow. The most common form of the disease affects a single lymph node (unicentric Castleman’s disease), usually in the chest or abdomen.
Multicenter Castleman’s disease affects multiple lymph nodes throughout the body and has been linked to human herpesvirus type 8 (HHV-8) and human immunodeficiency virus (HIV).
Treatment and outlook will vary depending on the type of Castleman’s disease you have. The type that only affects one lymph node can usually be operated on successfully. Castleman disease Treatment in Hyderabad
symptoms
Many people with single center Castleman’s disease don’t notice any signs or symptoms. The enlarged lymph node can be detected during a physical exam or an imaging test for an unrelated problem.
Some people with single center Castleman’s disease may have signs and symptoms that are more common with multi-center Castleman’s disease. This includes:
- fever
- Involuntary weight loss
- Tired
- Night sweats
- nausea
- Enlarged liver or spleen
The reasons
It is not known what causes Castleman’s disease. However, infection with a virus called human herpesvirus 8 (HHV-8) has been linked to multicenter Castleman’s disease.
The HHV-8 virus has also been linked to the development of Kaposi’s sarcoma, a cancerous tumor that can be a complication of HIV / AIDS. Studies have shown that HHV-8 is present in almost all HIV-positive people with Castleman’s disease and in about half of HIV-negative people with Castleman’s disease. Castleman disease Treatment in Hyderabad
Risk factors
Castleman’s disease can affect people of all ages. The median age of people diagnosed with unicentric Castleman’s disease is 35 years. Most people with the multicenter form are in their fifties and sixties. The multicenter form is also somewhat more common in men than in women.
People who are infected with a virus called human herpesvirus 8 (HHV-8) are at higher risk of developing multicenter Castleman’s disease. Castleman disease Treatment in Hyderabad