overview
Lining and villi of the small intestine
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Whipple disease is a rare bacterial infection that most commonly affects your joints and digestive system. Whipple’s disease affects normal digestion by changing the way foods are broken down and preventing your body from absorbing nutrients such as fats and carbohydrates. Intestinal lipodystrophy Treatment in Hyderabad
Whipple disease can infect other organs, including the brain, heart, and eyes.
Without adequate treatment, Whipple disease can be serious or fatal. However, antibiotic therapy can treat Whipple’s disease.
symptoms
Common signs and symptoms Digestive signs and symptoms are common in Whipple’s disease and can include:
- diarrhea
- Stomach pain and cramps that may work after meals
- Weight loss associated with nutrient malabsorption
- Other common signs and symptoms associated with Whipple disease include:
- Inflamed joints, especially the ankles, knees, and wrists
- Tired
- Weakness
- anemia
The reasons
Whipple disease is caused by a type of bacteria called Tropheryma whipplei. Bacteria first affect the lining of your small intestine, creating small wounds (lesions) in the intestinal wall. Bacteria also damage the fine-haired protrusions (villi) that line the small intestine.
Not much is known about bacteria. Although they appear to be easily present in the environment, scientists do not know where they came from or how they spread to humans. Not all people who carry the bacteria will develop the disease. Some researchers believe that people with this disease may have a genetic defect in their immune system response that makes them more likely to get sick when exposed to the bacteria.
Risk factors
Because so little is known about the bacteria responsible for Whipple disease, the risk factors for the disease have not been clearly identified. Based on the reports available, it seems more likely that the following is affected:
- Men aged 40 to 60 years
- Whites in North America and Europe
- Farmers and others who work outdoors and have frequent contact with sewage and sewage
Complications
The lining of your small intestine has fine, hair-like protrusions (villi) that help your body absorb nutrients. Whipple’s disease damages the villi and impairs nutrient absorption. Malnutrition is common in people with Whipple’s disease and can lead to fatigue, weakness, weight loss, and joint pain.
Whipple’s disease is a progressive and potentially fatal disease. Although infection is rare, deaths continue to be reported. Much of this is due to late diagnosis and delayed treatment. Often times, death is caused by the spread of an infection to the central nervous system that can cause irreversible damage. Intestinal lipodystrophy Treatment in Hyderabad